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demonstrated that TMAO activates NF-κB in aortic endothelial cells via mitogen-activated protein kinase (MAPK)/extracellular regulated protein kinases (ERK) signaling, promoting leukocyte adhesion and vascular inflammation (82)
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The peptide down-regulated oxidative phosphorylation, suppressed MYC target genes, and attenuated PI3K-AKT-mTOR signaling—pathways classically inhibited in validated lifespan-extending interventions
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