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As other Phase I studies using D+Q in the context of AD report out, we will be positioned to begin determining whether there is a convergence of data for specific disease states (e.g., NCT04785300 and NCT05422885 are both AD Phase I trials using D+Q), or study/site-specific changes are noted

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What differs is the fate of the hydroxyethyl group bound to thiamine pyrophosphate: in the reaction catalyzed by pyruvate dehydrogenase, this group is transferred to the next enzyme in the sequence, dihydrolipoyl transacetylase, whereas in the reaction catalyzed by pyruvate decarboxylase it is converted into acetaldehyde

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